Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.****Baggage protection services are available on selected flights only. Please read our T&Cs for more information.

How long does a flight take between Chicago and San Francisco?

The flight from Chicago to San Francisco has a duration of 5h 20m.

What are the cheapest flights from Chicago to San Francisco?

The cheapest one-way flight costs £164 flying with Southwest Airlines and the cheapest return flight costs £299 with Southwest Airlines.

How many airports are there in the city of Chicago?

Chicago has 3 airport: CHI - All airports, Chicago O'Hare International Airport, Midway International Airport.

How many airports does San Francisco have?

There are 2 airports in San Francisco: San Francisco International Airport, Oakland International Airport

Which San Francisco airport is the most central?

The most central airport is San Francisco International Airport, 17.9km.

Cheap flights from Chicago to San Francisco

Fly smart, spend less

Flights to San Francisco from Chicago

Cheap flights from Chicago to San Francisco from £164. Chicago (United States) - San Francisco (United States) return flights from £299. From 03/10/2026 (Saturday) - 11/10/2026 (Sunday). Check for the dates with the lowest prices and find the cheapest rates.

Round-trip flights from Chicago to San Francisco

Cheapest round-trip flights from Chicago to San Francisco

05 Oct - 12 Oct • 7 nights
21:25MDW
4h 45mDirect
00:10SFO
Southwest Airlines
23:40SFO
4h 10mDirect
05:50MDW
Southwest Airlines
from£299
05 Oct - 12 Oct • 7 nights
21:25MDW
4h 45mDirect
00:10SFO
Southwest Airlines
05:35SFO
4h 10mDirect
11:45MDW
Southwest Airlines
from£299
13 Oct - 17 Oct • 4 nights
20:55MDW
4h 45mDirect
23:40SFO
Southwest Airlines
23:40SFO
4h 10mDirect
05:50MDW
Southwest Airlines
from£299
05 Oct - 12 Oct • 7 nights
06:05MDW
6h 10m1 stop
10:15SFO
Southwest Airlines
23:40SFO
4h 10mDirect
05:50MDW
Southwest Airlines
from£314
05 Oct - 12 Oct • 7 nights
06:05MDW
6h 10m1 stop
10:15SFO
Southwest Airlines
05:35SFO
4h 10mDirect
11:45MDW
Southwest Airlines
from£314
13 Oct - 17 Oct • 4 nights
20:55MDW
4h 45mDirect
23:40SFO
Southwest Airlines
09:05SFO
4h 5mDirect
15:10MDW
Southwest Airlines
from£333

Explore all offers

Direct flights from Chicago to San Francisco

Book direct flights from Chicago to San Francisco for a smooth journey.

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Flights from Chicago to San Francisco one way

Find one-way flights from Chicago to San Francisco at great prices.

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Cheap flights from Chicago O'Hare International Airport to San Francisco

Find cheap flights from Chicago O'Hare International Airport to San Francisco now.

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Cheap flights from Midway International Airport to San Francisco

Find cheap flights from Midway International Airport to San Francisco now.

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Flights to San Francisco with top airlines

American Airlines
United Airlines
Southwest AirlinesCheapest
from £289.99

Chicago to San Francisco flight information

DEPARTING FROM:

Midway International Airport, more

ARRIVING IN:

San Francisco International Airport, more

AIRLINES:

American Airlines, Southwest Airlines, United Airlines

AVG FLIGHT TIME:

5h 20m

More information about flights to San Francisco from Chicago

Information about flights from Chicago to San Francisco

Need inspiration for your next holiday? Join lastminute.com’s facebook page and be sure to get top travel tips for your next trip .

Explore the additional services available on lastminute.com even once you have booked your flight Chicago-San Francisco . On lastminute.com, as well as your flight Chicago-San Francisco, you can also book car hire, ready for you on arrival in San Francisco. If you want to stay in San Francisco, our website has also created a way for you to book a hotel room in San Francisco with no fuss.

lastminute.com selects from hundreds of flight deals Chicago-San Francisco some of the best deals that month to save you time. Why not take advantage of the monthly flight offers and book now.

lastminute.com’s flight search finds you all available low cost flights from Chicago to San Francisco in just a few clicks. When looking for a low cost flight Chicago-San Francisco, simply specify departure and arrival dates and the maximum price you want to pay. It’s that simple!

If you are a frequent traveller , download our iPhone and Android app free of charge. It will change your travelling habits and be extremely useful whilst you are away on trips.

FAQs Chicago to San Francisco flights

FAQs

Can I combine different airlines on the same trip?
Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.
Is lastminute.com a trustworthy travel brand?
In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.
What options are there if I have to change my flight?
lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.*
*Flexibility services are available on selected flights only. Please read our T&Cs for more information.
I am afraid to lose my luggage, every time I fly. What can I do?
lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.**
**Baggage protection services are available on selected flights only. Please read our T&Cs for more information.
How long does a flight take between Chicago and San Francisco?
The flight from Chicago to San Francisco has a duration of 5h 20m.
What are the cheapest flights from Chicago to San Francisco?
The cheapest one-way flight costs £164 flying with Southwest Airlines and the cheapest return flight costs £299 with Southwest Airlines.
How many airports are there in the city of Chicago?
Chicago has 3 airport: CHI - All airports, Chicago O'Hare International Airport, Midway International Airport.
How many airports does San Francisco have?
There are 2 airports in San Francisco: San Francisco International Airport, Oakland International Airport
Which San Francisco airport is the most central?
The most central airport is San Francisco International Airport, 17.9km.