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Flights to San Francisco from Manchester

Cheap flights from Manchester to San Francisco from £464. Manchester (United Kingdom) - San Francisco (United States) return flights from £773. From 03/10/2026 (Saturday) - 08/10/2026 (Thursday). Check for the dates with the lowest prices and find the cheapest rates.

More information about flights to San Francisco from Manchester

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FAQs Manchester to San Francisco flights

FAQs

  • Can I combine different airlines on the same trip?

    Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

  • Is lastminute.com a trustworthy travel brand?

    In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

  • What options are there if I have to change my flight?

    lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.*

  • I am afraid to lose my luggage, every time I fly. What can I do?

    lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.**

  • How long does a flight take between Manchester and San Francisco?

    The flight from Manchester to San Francisco has a duration of 17h 9m.

  • What are the cheapest flights from Manchester to San Francisco?

    The cheapest one-way flight costs £464 flying with Virgin Atlantic Airways and the cheapest return flight costs £773 with Aer Lingus.

  • How many airports are there in the city of Manchester?

    Manchester has 1 airport: Manchester Airport.

  • How many airports does San Francisco have?

    There are 1 airports in San Francisco: San Francisco International Airport

  • Which San Francisco airport is the most central?

    The most central airport is San Francisco International Airport, 17.9km.

  • Schedules of the first and last flight from Manchester to San Francisco

    The first flight from Manchester to San Francisco is at 12:50 and the last flight departs at 16:40.