Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.****Baggage protection services are available on selected flights only. Please read our T&Cs for more information.

How long does a flight take between Madrid and Brussels?

The flight from Madrid to Brussels has a duration of 2h 22m.

What are the cheapest flights from Madrid to Brussels?

The cheapest one-way flight costs £67 flying with Air Europa and the cheapest return flight costs £101 with Brussels Airlines.

How many airports are there in the city of Madrid?

Madrid has 1 airport: Adolfo Suarez Madrid-Barajas Airport.

How many airports does Brussels have?

There are 3 airports in Brussels: Charleroi Airport, Brussels Airport, Antwerp International Airport

Which Brussels airport is the most central?

The most central airport is Brussels Airport, 10.7km.

Which airlines have flights from Madrid to Brussels?

There are 4 airlines with flights from Madrid to Brussels; Those that offer lower prices are Ryanair (£82), Brussels Airlines (£237), Air Europa (£129).

Schedules of the first and last flight from Madrid to Brussels

The first flight from Madrid to Brussels is at 08:35 and the last flight departs at 23:10.

Cheap flights from Madrid to Brussels

Fly smart, spend less

Flights to Brussels from Madrid

Cheap flights from Madrid to Brussels from £67. Madrid (Spain) - Brussels (Belgium) return flights from £101. From 14/11/2026 (Saturday) - 16/11/2026 (Monday). Check for the dates with the lowest prices and find the cheapest rates.

Round-trip flights from Madrid to Brussels

Cheapest round-trip flights from Madrid to Brussels

10 Nov - 14 Nov • 4 nights
06:25MAD
2h 25mDirect
08:50BRU
Brussels Airlines
09:20BRU
2h 25mDirect
11:45MAD
Brussels Airlines
from£101
10 Nov - 15 Nov • 5 nights
06:25MAD
2h 25mDirect
08:50BRU
Brussels Airlines
14:15BRU
2h 25mDirect
16:40MAD
Brussels Airlines
from£101
13 Nov - 17 Nov • 4 nights
20:45MAD
2h 25mDirect
23:10BRU
Brussels Airlines
14:15BRU
2h 25mDirect
16:40MAD
Brussels Airlines
from£101
13 Nov - 17 Nov • 4 nights
06:25MAD
2h 25mDirect
08:50BRU
Brussels Airlines
14:15BRU
2h 25mDirect
16:40MAD
Brussels Airlines
from£101
13 Nov - 17 Nov • 4 nights
06:25MAD
2h 25mDirect
08:50BRU
Brussels Airlines
09:20BRU
2h 25mDirect
11:45MAD
Brussels Airlines
from£101
13 Nov - 17 Nov • 4 nights
20:45MAD
2h 25mDirect
23:10BRU
Brussels Airlines
09:20BRU
2h 25mDirect
11:45MAD
Brussels Airlines
from£101

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Direct flights from Madrid to Brussels

Book direct flights from Madrid to Brussels for a smooth journey.

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Flights from Madrid to Brussels one way

Find one-way flights from Madrid to Brussels at great prices.

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Iberia flights from Madrid to Brussels

Fly with Iberia from Madrid to Brussels for less.

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Madrid to Brussels flight information

DEPARTING FROM:

Adolfo Suarez Madrid-Barajas Airport

ARRIVING IN:

Brussels Airport, Antwerp International Airport, more

AIRLINES:

Air Europa, Brussels Airlines, Iberia, Ryanair

AVG FLIGHT TIME:

2h 22m

More information about flights to Brussels from Madrid

Information about flights from Madrid to Brussels

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As well as your flight from Madrid to Brussels , guess what, it’s also really easy with lastminute.com to have a car waiting for you when you arrive as well as accommodation in Brussels.

If you don’t know where to go on holiday, why not let yourself be guided by our cheap flight deals to Brussels from Madrid. Without the stress of having set dates, the search results will help you make up your mind.

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FAQs Madrid to Brussels flights

FAQs

Can I combine different airlines on the same trip?
Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.
Is lastminute.com a trustworthy travel brand?
In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.
What options are there if I have to change my flight?
lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.*
*Flexibility services are available on selected flights only. Please read our T&Cs for more information.
I am afraid to lose my luggage, every time I fly. What can I do?
lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.**
**Baggage protection services are available on selected flights only. Please read our T&Cs for more information.
How long does a flight take between Madrid and Brussels?
The flight from Madrid to Brussels has a duration of 2h 22m.
What are the cheapest flights from Madrid to Brussels?
The cheapest one-way flight costs £67 flying with Air Europa and the cheapest return flight costs £101 with Brussels Airlines.
How many airports are there in the city of Madrid?
Madrid has 1 airport: Adolfo Suarez Madrid-Barajas Airport.
How many airports does Brussels have?
There are 3 airports in Brussels: Charleroi Airport, Brussels Airport, Antwerp International Airport
Which Brussels airport is the most central?
The most central airport is Brussels Airport, 10.7km.
Which airlines have flights from Madrid to Brussels?
There are 4 airlines with flights from Madrid to Brussels; Those that offer lower prices are Ryanair (£82), Brussels Airlines (£237), Air Europa (£129).
Schedules of the first and last flight from Madrid to Brussels
The first flight from Madrid to Brussels is at 08:35 and the last flight departs at 23:10.