Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

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In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

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How long does a flight take between Madrid and Brussels?

The flight from Madrid to Brussels has a duration of 2h 23m.

What are the cheapest flights from Madrid to Brussels?

The cheapest one-way flight costs £32 flying with Ryanair and the cheapest return flight costs £80 with Ryanair.

How many airports are there in the city of Madrid?

Madrid has 1 airport: MAD - All airports.

How many airports does Brussels have?

There are 3 airports in Brussels: BRU - All airports, Charleroi Airport, ANR - All airports

Which Brussels airport is the most central?

The most central airport is BRU - All airports, 20.5km.

Which airlines have flights from Madrid to Brussels?

There are 4 airlines with flights from Madrid to Brussels; Those that offer lower prices are Ryanair (£77), Brussels Airlines (£246), Air Europa (£129).

Schedules of the first and last flight from Madrid to Brussels

The first flight from Madrid to Brussels is at 08:20 and the last flight departs at 23:10.

Cheap flights from Madrid to Brussels

Fly smart, spend less

Flights to Brussels from Madrid

Cheap flights from Madrid to Brussels from £32. Madrid (Spain) - Brussels (Belgium) return flights from £80. From 09/09/2026 (Wednesday) - 14/09/2026 (Monday). Check for the dates with the lowest prices and find the cheapest rates.

Direct flights from Madrid to Brussels

Book direct flights from Madrid to Brussels for a smooth journey.

10 Sept - 14 Sept • 4 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

15 Jul - 22 Jul • 7 nights

Flights from Madrid to Brussels one way

Find one-way flights from Madrid to Brussels at great prices.

04 Jul

03 Jul

06 Jul

07 Jul

07 Jul

03 Jul

Cheapest flights from Madrid to Brussels

Get the cheapest flights from Madrid to Brussels today.

10 Sept - 14 Sept • 4 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

15 Jul - 22 Jul • 7 nights

Cheap flights from MAD - All airports to Brussels

Find cheap flights from MAD - All airports to Brussels now.

10 Sept - 14 Sept • 4 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

15 Jul - 22 Jul • 7 nights

Iberia flights from Madrid to Brussels

Fly with Iberia from Madrid to Brussels for less.

10 Sept - 14 Sept • 4 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

05 Aug - 13 Aug • 8 nights

04 Aug - 13 Aug • 9 nights

23 Jun - 27 Jun • 4 nights

Madrid to Brussels flight information

DEPARTING FROM:

MAD - All airports

ARRIVING IN:

BRU - All airports, ANR - All airports, Charleroi Airport

AIRLINES:

Air Europa, Brussels Airlines, Iberia, Ryanair

AVG FLIGHT TIME:

2h 23m

More information about flights to Brussels from Madrid

Information about flights from Madrid to Brussels

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FAQs Madrid to Brussels flights

FAQs

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

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