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Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

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In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

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How long does a flight take between Madrid and Brussels?

The flight from Madrid to Brussels has a duration of 2h 23m.

What are the cheapest flights from Madrid to Brussels?

The cheapest one-way flight costs £56 flying with Ryanair and the cheapest return flight costs £321 with Brussels Airlines.

How many airports are there in the city of Madrid?

Madrid has 1 airport: Adolfo Suarez Madrid-Barajas Airport.

How many airports does Brussels have?

There are 3 airports in Brussels: Brussels Airport, Charleroi Airport, Antwerp International Airport

Which Brussels airport is the most central?

The most central airport is Brussels Airport, 10.7km.

Which airlines have flights from Madrid to Brussels?

There are 4 airlines with flights from Madrid to Brussels; Those that offer lower prices are Iberia (£59), Brussels Airlines (£246), Air Europa (£67).

Schedules of the first and last flight from Madrid to Brussels

The first flight from Madrid to Brussels is at 08:35 and the last flight departs at 22:30.

Cheap flights from Madrid to Brussels

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Flights to Brussels from Madrid

Cheap flights from Madrid to Brussels from £56. Madrid (Spain) - Brussels (Belgium) return flights from £321. From 24/07/2026 (Friday) - 27/07/2026 (Monday). Check for the dates with the lowest prices and find the cheapest rates.

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Cheap flights from Madrid to Brussels

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Flights to Brussels from Madrid

Direct flights from Madrid to Brussels

Flights from Madrid to Brussels one way

Cheapest flights from Madrid to Brussels

Cheap flights from Adolfo Suarez Madrid-Barajas Airport to Brussels

Iberia flights from Madrid to Brussels

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Madrid to Brussels flight information

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Information about flights from Madrid to Brussels