Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.****Baggage protection services are available on selected flights only. Please read our T&Cs for more information.

How long does a flight take between Prague and Brussels?

The flight from Prague to Brussels has a duration of 1h 30m.

What are the cheapest flights from Prague to Brussels?

The cheapest one-way flight costs £58 flying with Ryanair and the cheapest return flight costs £48 with Ryanair.

How many airports are there in the city of Prague?

Prague has 1 airport: Vaclav Havel Airport Prague.

How many airports does Brussels have?

There are 2 airports in Brussels: Brussels Airport, Charleroi Airport

Which Brussels airport is the most central?

The most central airport is Brussels Airport, 10.7km.

Which airlines have flights from Prague to Brussels?

There are 4 airlines with flights from Prague to Brussels; Those that offer lower prices are Ryanair (£54), Brussels Airlines (£175).

Schedules of the first and last flight from Prague to Brussels

The first flight from Prague to Brussels is at 08:20 and the last flight departs at 22:45.

Cheap flights from Prague to Brussels

Fly smart, spend less

Flights to Brussels from Prague

Cheap flights from Prague to Brussels from £58. Prague (Czech Republic) - Brussels (Belgium) return flights from £48. From 30/09/2026 (Wednesday) - 06/10/2026 (Tuesday). Check for the dates with the lowest prices and find the cheapest rates.

Round-trip flights from Prague to Brussels

Cheapest round-trip flights from Prague to Brussels

30 Sept - 06 Oct • 6 nights
21:15PRG
1h 30mDirect
22:45CRL
Ryanair
07:55CRL
1h 30mDirect
09:25PRG
Ryanair
from£48
30 Sept - 06 Oct • 6 nights
21:15PRG
1h 30mDirect
22:45CRL
Ryanair
12:10CRL
1h 30mDirect
13:40PRG
Ryanair
from£61
18 Nov - 21 Nov • 3 nights
09:40PRG
1h 30mDirect
11:10CRL
Ryanair
14:25CRL
1h 30mDirect
15:55PRG
Ryanair
from£78
25 Sept - 28 Sept • 3 nights
21:15PRG
1h 30mDirect
22:45CRL
Ryanair
13:35CRL
1h 30mDirect
15:05PRG
Ryanair
from£193

Explore all offers

Direct flights from Prague to Brussels

Book direct flights from Prague to Brussels for a smooth journey.

Explore all offers

Flights from Prague to Brussels one way

Find one-way flights from Prague to Brussels at great prices.

Explore all offers

Prague to Brussels flight information

DEPARTING FROM:

Vaclav Havel Airport Prague

ARRIVING IN:

Brussels Airport, Charleroi Airport

AIRLINES:

Brussels Airlines, CSA, Ryanair, Smart Wings

AVG FLIGHT TIME:

1h 30m

More information about flights to Brussels from Prague

Information about flights from Prague to Brussels

lastminute.com’s facebook page gives you an easy way to stay up to date with giveaways and promotions on low cost flights and holidays to Brussels from Prague.

As well as your flight from Prague to Brussels , guess what, it’s also really easy with lastminute.com to have a car waiting for you when you arrive as well as accommodation in Brussels.

Welcome to the lastminute.com travel website! You have arrived in the right place if you are looking for a low cost flight Prague-Brussels . Complete the form on the flight search engine correctly, and we are sure to have what you are looking for.

When you’re looking to get away and not interested in a precise date, take a look at our flight offers this month. Flight deals from Prague to Brussels are great time of year. Be inspired!

If you are a frequent traveller , lastminute.com would like to be your trusted one stop travel partner in helping you find flights, hotels and car hire in Brussels and worldwide.

FAQs Prague to Brussels flights

FAQs

Can I combine different airlines on the same trip?
Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.
Is lastminute.com a trustworthy travel brand?
In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.
What options are there if I have to change my flight?
lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.*
*Flexibility services are available on selected flights only. Please read our T&Cs for more information.
I am afraid to lose my luggage, every time I fly. What can I do?
lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.**
**Baggage protection services are available on selected flights only. Please read our T&Cs for more information.
How long does a flight take between Prague and Brussels?
The flight from Prague to Brussels has a duration of 1h 30m.
What are the cheapest flights from Prague to Brussels?
The cheapest one-way flight costs £58 flying with Ryanair and the cheapest return flight costs £48 with Ryanair.
How many airports are there in the city of Prague?
Prague has 1 airport: Vaclav Havel Airport Prague.
How many airports does Brussels have?
There are 2 airports in Brussels: Brussels Airport, Charleroi Airport
Which Brussels airport is the most central?
The most central airport is Brussels Airport, 10.7km.
Which airlines have flights from Prague to Brussels?
There are 4 airlines with flights from Prague to Brussels; Those that offer lower prices are Ryanair (£54), Brussels Airlines (£175).
Schedules of the first and last flight from Prague to Brussels
The first flight from Prague to Brussels is at 08:20 and the last flight departs at 22:45.