Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

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How long does a flight take between Prague and Santorini?

The flight from Prague to Santorini has a duration of 3h 48m.

What are the cheapest flights from Prague to Santorini?

The cheapest one-way flight costs £108 flying with Smart Wings and the cheapest return flight costs £268 with Smart Wings.

How many airports are there in the city of Prague?

Prague has 1 airport: Vaclav Havel Airport Prague.

How many airports does Santorini have?

There are 1 airports in Santorini: Santorini International Airport

Which Santorini airport is the most central?

The most central airport is Santorini International Airport, 4.2km.

Schedules of the first and last flight from Prague to Santorini

The first flight from Prague to Santorini is at 08:50 and the last flight departs at 08:50.

Cheap flights from Prague to Santorini

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Flights to Santorini from Prague

Cheap flights from Prague to Santorini from £108. Prague (Czech Republic) - Santorini (Greece) return flights from £268. From 31/07/2026 (Friday) - 04/08/2026 (Tuesday). Check for the dates with the lowest prices and find the cheapest rates.

Cheap flights from Prague to Santorini

Fly smart, spend less

Flights to Santorini from Prague

Direct flights from Prague to Santorini

Flights from Prague to Santorini one way

Cheapest flights from Prague to Santorini

Cheap flights from Vaclav Havel Airport Prague to Santorini

More information about flights to Santorini from Prague

Information about flights from Prague to Santorini