Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

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How long does a flight take between Prague and Rome?

The flight from Prague to Rome has a duration of 1h 54m.

What are the cheapest flights from Prague to Rome?

The cheapest one-way flight costs £36 flying with Ryanair and the cheapest return flight costs £131 with Wizz Air Malta.

How many airports are there in the city of Prague?

Prague has 1 airport: Vaclav Havel Airport Prague.

How many airports does Rome have?

There are 3 airports in Rome: ROM - All airports, Fiumicino Airport, Rome Ciampino Airport

Which Rome airport is the most central?

The most central airport is ROM - All airports, 12.8km.

Which airlines have flights from Prague to Rome?

There are 5 airlines with flights from Prague to Rome; Those that offer lower prices are Ryanair (£38), Wizz Air Malta (£56), Smart Wings (£80).

Schedules of the first and last flight from Prague to Rome

The first flight from Prague to Rome is at 10:05 and the last flight departs at 21:45.

Cheap flights from Prague to Rome

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Flights to Rome from Prague

Cheap flights from Prague to Rome from £36. Prague (Czech Republic) - Rome (Italy) return flights from £131. From 11/07/2026 (Saturday) - 14/07/2026 (Tuesday). Check for the dates with the lowest prices and find the cheapest rates.