Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

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How long does a flight take between Rome and Istanbul?

The flight from Rome to Istanbul has a duration of 2h 40m.

What are the cheapest flights from Rome to Istanbul?

The cheapest one-way flight costs £88 flying with Valuair and the cheapest return flight costs £211 with Valuair.

How many airports are there in the city of Rome?

Rome has 2 airport: ROM - All airports, Rome Ciampino Airport.

How many airports does Istanbul have?

There are 1 airports in Istanbul: IST - All airports

Which Istanbul airport is the most central?

The most central airport is IST - All airports, 3.9km.

Schedules of the first and last flight from Rome to Istanbul

The first flight from Rome to Istanbul is at 10:45 and the last flight departs at 23:35.

Cheap flights from Rome to Istanbul

Fly smart, spend less

Flights to Istanbul from Rome

Cheap flights from Rome to Istanbul from £88. Rome (Italy) - Istanbul (Turkey) return flights from £211. From 22/06/2026 (Monday) - 28/06/2026 (Sunday). Check for the dates with the lowest prices and find the cheapest rates.

Direct flights from Rome to Istanbul

Book direct flights from Rome to Istanbul for a smooth journey.

22 Jun - 28 Jun • 6 nights

02 Jul - 10 Jul • 8 nights

29 Aug - 06 Sept • 8 nights

10 Jul - 12 Jul • 2 nights

29 Aug - 06 Sept • 8 nights

27 Jul - 30 Jul • 3 nights

Flights from Rome to Istanbul one way

Find one-way flights from Rome to Istanbul at great prices.

10 Jun

13 Jun

11 Jun

06 Sept

29 Aug

02 Sept

Cheapest flights from Rome to Istanbul

Get the cheapest flights from Rome to Istanbul today.

10 Jul - 12 Jul • 2 nights

13:40FCO

19h 50m1 stop

10:30IST

LOT - Polish Airlines

11:30IST

26h 10m1 stop

12:40FCO

LOT - Polish Airlines

from£210

22 Jun - 28 Jun • 6 nights

27 Jul - 30 Jul • 3 nights

13:40FCO

19h 50m1 stop

10:30IST

LOT - Polish Airlines

13:55IST

20h 50m1 stop

09:45FCO

LOT - Polish Airlines

from£226

29 Aug - 06 Sept • 8 nights

19:05FCO

20h 35m1 stop

16:40IST

LOT - Polish Airlines

11:30IST

26h 10m1 stop

12:40FCO

LOT - Polish Airlines

from£238

29 Aug - 06 Sept • 8 nights

LOT - Polish Airlines

from£242

02 Jul - 10 Jul • 8 nights

19:05FCO

17h1 stop

13:05IST

LOT - Polish Airlines

07:00IST

12h 5m1 stop

18:05FCO

LOT - Polish Airlines

from£243

Explore all offers

More information about flights to Istanbul from Rome

Information about flights from Rome to Istanbul

Once your flight Rome-Istanbul is booked, using lastminute.com you can even organise the rest of your trip. From car hire and accommodation in Istanbul as well as a guide to Istanbul so you know in advance what there is to see and do.

Not only can you use the lastminute.com website to search low cost flights, but we have even preselected some flight offers from Rome to Istanbul for you to save you time.

lastminute.com’s facebook page gives you an easy way to stay up to date with giveaways and promotions on low cost flights and holidays to Istanbul from Rome.

If you are a frequent traveller , lastminute.com would like to be your trusted one stop travel partner in helping you find flights, hotels and car hire in Istanbul and worldwide.

Welcome to the lastminute.com travel website! You have arrived in the right place if you are looking for a low cost flight Rome-Istanbul . Complete the form on the flight search engine correctly, and we are sure to have what you are looking for.

FAQs Rome to Istanbul flights

FAQs

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

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