Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.****Baggage protection services are available on selected flights only. Please read our T&Cs for more information.

How long does a flight take between Santorini and Rome?

The flight from Santorini to Rome has a duration of 2h 38m.

What are the cheapest flights from Santorini to Rome?

The cheapest one-way flight costs £45 flying with Ryanair and the cheapest return flight costs £70 with Ryanair.

How many airports are there in the city of Santorini?

Santorini has 1 airport: Santorini International Airport.

How many airports does Rome have?

There are 3 airports in Rome: ROM - All airports, Fiumicino Airport, Rome Ciampino Airport

Which Rome airport is the most central?

The most central airport is ROM - All airports, 12.8km.

Which airlines have flights from Santorini to Rome?

There are 2 airlines with flights from Santorini to Rome; Those that offer lower prices are Ryanair (£142).

Schedules of the first and last flight from Santorini to Rome

The first flight from Santorini to Rome is at 15:45 and the last flight departs at 00:55.

Cheap flights from Santorini to Rome

Fly smart, spend less

Flights to Rome from Santorini

Cheap flights from Santorini to Rome from £45. Santorini (Greece) - Rome (Italy) return flights from £70. From 16/10/2026 (Friday) - 19/10/2026 (Monday). Check for the dates with the lowest prices and find the cheapest rates.

Round-trip flights from Fira to Rome

Cheapest round-trip flights from Fira to Rome

08 Oct - 11 Oct • 3 nights
23:50JTR
2h 25mDirect
01:15FCO
Ryanair
06:05FCO
2h 10mDirect
09:15JTR
Ryanair
from£70
16 Oct - 19 Oct • 3 nights
22:35JTR
2h 24mDirect
23:59FCO
Ryanair
13:55FCO
2h 10mDirect
17:05JTR
Ryanair
from£70
15 Oct - 19 Oct • 4 nights
23:50JTR
2h 25mDirect
01:15FCO
Ryanair
13:55FCO
2h 10mDirect
17:05JTR
Ryanair
from£79
16 Oct - 19 Oct • 3 nights
22:35JTR
2h 24mDirect
23:59FCO
Ryanair
13:00FCO
3h 45m1 stop
17:45JTR
Sky Express
from£189
15 Oct - 19 Oct • 4 nights
23:50JTR
2h 25mDirect
01:15FCO
Ryanair
13:00FCO
3h 45m1 stop
17:45JTR
Sky Express
from£220
08 Oct - 11 Oct • 3 nights
23:50JTR
2h 25mDirect
01:15FCO
Ryanair
13:00FCO
3h 45m1 stop
17:45JTR
Sky Express
from£233

Explore all offers

Direct flights from Fira to Rome

Book direct flights from Fira to Rome for a smooth journey.

Explore all offers

Flights from Fira to Rome one way

Find one-way flights from Fira to Rome at great prices.

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Ryanair flights from Fira to Rome

Fly with Ryanair from Fira to Rome for less.

Explore all offers

Santorini to Rome flight information

DEPARTING FROM:

Santorini International Airport

ARRIVING IN:

ROM - All airports, Rome Ciampino Airport, Fiumicino Airport

AIRLINES:

Ryanair, Wizz Air Malta

AVG FLIGHT TIME:

2h 38m

More information about flights to Rome from Santorini

Information about flights from Santorini to Rome

Low cost flights to Rome from Santorini are not always easy to find. lastminute.com wants to make it easy for you to find a inexpensive option, so with us you can even choose flights with different airlines and save money on your next trip .

Why limit yourself to the lastminute.com desktop travel website services – download our iPhone and Android App and get full use of all the services even whilst you’re on holiday.

lastminute.com App for iPhone and Android – the solution to your travelling needs. Perfect if you are always on the move, need to book your travel from anywhere quickly and easily. Take this practical and reliable tool with you on your travels .

lastminute.com’s flight search finds you all available low cost flights from Santorini to Rome in just a few clicks. When looking for a low cost flight Santorini-Rome, simply specify departure and arrival dates and the maximum price you want to pay. It’s that simple!

Take advantage of our flight offers to Rome from Santorini . This month’s best flight deals have been specially selected for you.

FAQs Santorini to Rome flights

FAQs

Can I combine different airlines on the same trip?
Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.
Is lastminute.com a trustworthy travel brand?
In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.
What options are there if I have to change my flight?
lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.*
*Flexibility services are available on selected flights only. Please read our T&Cs for more information.
I am afraid to lose my luggage, every time I fly. What can I do?
lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.**
**Baggage protection services are available on selected flights only. Please read our T&Cs for more information.
How long does a flight take between Santorini and Rome?
The flight from Santorini to Rome has a duration of 2h 38m.
What are the cheapest flights from Santorini to Rome?
The cheapest one-way flight costs £45 flying with Ryanair and the cheapest return flight costs £70 with Ryanair.
How many airports are there in the city of Santorini?
Santorini has 1 airport: Santorini International Airport.
How many airports does Rome have?
There are 3 airports in Rome: ROM - All airports, Fiumicino Airport, Rome Ciampino Airport
Which Rome airport is the most central?
The most central airport is ROM - All airports, 12.8km.
Which airlines have flights from Santorini to Rome?
There are 2 airlines with flights from Santorini to Rome; Those that offer lower prices are Ryanair (£142).
Schedules of the first and last flight from Santorini to Rome
The first flight from Santorini to Rome is at 15:45 and the last flight departs at 00:55.