Can I combine different airlines on the same trip?

Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.

Is lastminute.com a trustworthy travel brand?

In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.

What options are there if I have to change my flight?

lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.**Flexibility services are available on selected flights only. Please read our T&Cs for more information.

I am afraid to lose my luggage, every time I fly. What can I do?

lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.****Baggage protection services are available on selected flights only. Please read our T&Cs for more information.

How long does a flight take between Madrid and Santo Domingo?

The flight from Madrid to Santo Domingo has a duration of 9h 11m.

What are the cheapest flights from Madrid to Santo Domingo?

The cheapest one-way flight costs £261 flying with World 2 Fly, S.L and the cheapest return flight costs £495 with Iberia.

How many airports are there in the city of Madrid?

Madrid has 1 airport: Adolfo Suarez Madrid-Barajas Airport.

How many airports does Santo Domingo have?

There are 1 airports in Santo Domingo: Las Americas Airport

Which Santo Domingo airport is the most central?

The most central airport is Las Americas Airport, 23.2km.

Which airlines have flights from Madrid to Santo Domingo?

There are 3 airlines with flights from Madrid to Santo Domingo; Those that offer lower prices are World 2 Fly, S.L (£441), Iberia (£593), Air Europa (£664).

Schedules of the first and last flight from Madrid to Santo Domingo

The first flight from Madrid to Santo Domingo is at 13:50 and the last flight departs at 20:35.

Cheap flights from Madrid to Santo Domingo

Fly smart, spend less

Flights to Santo Domingo from Madrid

Cheap flights from Madrid to Santo Domingo from £261. Madrid (Spain) - Santo Domingo (Dominican Republic) return flights from £495. From 18/11/2026 (Wednesday) - 25/11/2026 (Wednesday). Check for the dates with the lowest prices and find the cheapest rates.

Round trip

Direct

One Way

Iberia

Cheapest flights from Madrid to Santo Domingo

Get the cheapest flights from Madrid to Santo Domingo today.

18 Nov - 24 Nov • 6 nights
09:15MAD
9h 35m
Direct
13:50SDQ
Iberia
22:05SDQ
8h 15m
Direct
11:20MAD
Iberia
from£495
18 Nov - 24 Nov • 6 nights
09:15MAD
9h 35m
Direct
13:50SDQ
Iberia
15:20SDQ
8h 30m
Direct
04:50MAD
Iberia
from£495
18 Nov - 24 Nov • 6 nights
16:10MAD
9h
Direct
20:10SDQ
Air Europa
22:05SDQ
8h 5m
Direct
11:10MAD
Air Europa
from£512
24 Nov - 29 Nov • 5 nights
09:15MAD
9h 35m
Direct
13:50SDQ
Iberia
22:05SDQ
8h 15m
Direct
11:20MAD
Iberia
from£520
24 Nov - 29 Nov • 5 nights
09:15MAD
9h 35m
Direct
13:50SDQ
Iberia
15:20SDQ
8h 30m
Direct
04:50MAD
Iberia
from£520
18 Nov - 24 Nov • 6 nights
09:15MAD
9h 35m
Direct
13:50SDQ
Iberia
18:00SDQ
8h 15m
Direct
07:15MAD
Iberia
from£545

Explore all offers

Direct flights from Madrid to Santo Domingo

Book direct flights from Madrid to Santo Domingo for a smooth journey.

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Flights from Madrid to Santo Domingo one way

Find one-way flights from Madrid to Santo Domingo at great prices.

Explore all offers

Iberia flights from Madrid to Santo Domingo

Fly with Iberia from Madrid to Santo Domingo for less.

Explore all offers

Flights to Santo Domingo with top airlines

Iberia
Cheapest
from £494.99
Air Europa
from £511.99

Madrid to Santo Domingo flight information

DEPARTING FROM:

Adolfo Suarez Madrid-Barajas Airport

ARRIVING IN:

Las Americas Airport

AIRLINES:

Air Europa, Iberia, World 2 Fly, S.L

AVG FLIGHT TIME:

9h 11m

More information about flights to Santo Domingo from Madrid

Good to know

Information about flights from Madrid to Santo Domingo

Once you have your flight Madrid-Santo Domingo booked you can always use lastminute.com to organise the rest of your trip just the way you want it. lastminute.com allows you to book a hotel, car hire, tours and activities in Santo Domingo.

lastminute.com would like to be the perfect travel tool for all your travelling needs . The lastminute.com App is also available for the smartphone so you don’t miss out and being able to use our search engine from wherever you are.

Not only can you use the lastminute.com website to search low cost flights, but we have even preselected some flight offers from Madrid to Santo Domingo for you to save you time.

Need inspiration for your next holiday? Join lastminute.com’s facebook page and be sure to get top travel tips for your next trip .

Hi and welcome to your perfect solution to finding low cost flights in just a few clicks! When searching for a low cost flight from Madrid to Santo Domingo , all you have to do is complete the search form and in no time you will be flying off to Santo Domingo.

FAQs Madrid to Santo Domingo flights

FAQs

Can I combine different airlines on the same trip?
Of course. We offer you the possibility of booking with more than 400 airlines so that you can find the cheapest fare or the most convenient combination: outbound flight with one airline and return flight with another.
Is lastminute.com a trustworthy travel brand?
In 1998, lastminute.com was one of the first online travel agencies. Currently, we are selling over 380,000 flights per year – and working hard on bringing travellers wherever they want to go.
What options are there if I have to change my flight?
lastminute.com offers flexibility services for purchase at the time of your booking. These services entitle you to change or cancel your flights without handling fee.*
*Flexibility services are available on selected flights only. Please read our T&Cs for more information.
I am afraid to lose my luggage, every time I fly. What can I do?
lastminute.com offers a range of baggage protection services, so that you are covered in case your luggage is delayed or lost.**
**Baggage protection services are available on selected flights only. Please read our T&Cs for more information.
How long does a flight take between Madrid and Santo Domingo?
The flight from Madrid to Santo Domingo has a duration of 9h 11m.
What are the cheapest flights from Madrid to Santo Domingo?
The cheapest one-way flight costs £261 flying with World 2 Fly, S.L and the cheapest return flight costs £495 with Iberia.
How many airports are there in the city of Madrid?
Madrid has 1 airport: Adolfo Suarez Madrid-Barajas Airport.
How many airports does Santo Domingo have?
There are 1 airports in Santo Domingo: Las Americas Airport
Which Santo Domingo airport is the most central?
The most central airport is Las Americas Airport, 23.2km.
Which airlines have flights from Madrid to Santo Domingo?
There are 3 airlines with flights from Madrid to Santo Domingo; Those that offer lower prices are World 2 Fly, S.L (£441), Iberia (£593), Air Europa (£664).
Schedules of the first and last flight from Madrid to Santo Domingo
The first flight from Madrid to Santo Domingo is at 13:50 and the last flight departs at 20:35.

Cheap flights London - Santo Domingo